Taken from the Declaration of Independence of the United States.
"But when a long train of abuses and usurpations, pursuing invariably the same Object evinces a design to reduce them under absolute Despotism, it is their right, it is their duty, to throw off such Government, and provide new Guards for their future security."
By Benjamin Franklin Gates' explanation in the movie National Treasure, it means if there's something wrong, those who have the ability to take action have the responsibility to take action.
*I read the full text of the historical paper and couldn't understand who are the people written in it referring to. It's like no other text I've seen. I love the part when Nicholas Cage said that excerpt above. Super cool voice.